Research workbench

Beta-lactamase, unmixed

Analyse Beta-lactamase, unmixed in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7K8L
Type: protein
Length: 1,060 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: A0A655AHQ9
Ligands: PO4
Pockets: 11 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Beta-lactamase (EC 3.5.2.6)	protein	265	41% helix, 17% strand	A0A655AHQ9

Ligands and binding sites

PO4 · Phosphate ion · ion · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.67	0.83	37	PO4
2	579	0.63	0.75	53	PO4
3	189	0.62	0.84	28	PO4
4	470	0.61	0.75	42	PO4
5	183	0.49	0.77	39	empty

Interfaces

4 interfaces between chains.

A–B · 757 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 735 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 614 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 596 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7K8L · Beta-lactamase, Unmixed · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A655AHQ9
Elsewhere: RCSB PDB 7K8L · PDBe 7K8L · UniProt A0A655AHQ9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.