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BETAB2-crystallin

Analyse BETAB2-crystallin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7K7U
Type: protein
Length: 2,221 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-crystallin B2
UniProt: P43320
Pockets: 6 · best druggability 0.70

Structure

x-ray diffraction · 8 distinct chains · 6% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
I, L	Beta-crystallin B2	protein	184	7% helix, 42% strand	P43320
J, B	Beta-crystallin B2	protein	187	2% helix, 44% strand	P43320
K, A, C	Beta-crystallin B2	protein	186	5% helix, 42% strand	P43320
D	Beta-crystallin B2	protein	185	9% helix, 45% strand	P43320
E	Beta-crystallin B2	protein	185	7% helix, 42% strand	P43320
F	Beta-crystallin B2	protein	184	9% helix, 45% strand	P43320
G	Beta-crystallin B2	protein	184	4% helix, 42% strand	P43320
H	Beta-crystallin B2	protein	183	9% helix, 42% strand	P43320

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	846	0.70	0.76	108	empty
2	762	0.69	0.76	105	empty
3	565	0.67	0.77	87	empty
4	253	0.53	0.76	39	empty
5	107	0.33	0.72	16	empty

Interfaces

21 interfaces between chains.

I–L · 2317 Å² buried · 34 hydrogen bonds · protein-protein
J–K · 2311 Å² buried · 38 hydrogen bonds · protein-protein
A–D · 2230 Å² buried · 35 hydrogen bonds · protein-protein
B–G · 2202 Å² buried · 34 hydrogen bonds · protein-protein
C–E · 2193 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

7K7U · BetaB2-crystallin · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43320
Elsewhere: RCSB PDB 7K7U · PDBe 7K7U · UniProt P43320

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