Research workbench
Crystal structure of human MORC4 ATPase-cw in complex with amppnp
Analyse Crystal structure of human MORC4 ATPase-cw in complex with amppnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7K7T
- Type
- protein
- Length
- 776 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 3 of morc family cw-type zinc finger protein 4
- UniProt
- Q8TE76
- Ligands
- ANP, ZN, MG
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 3 of morc family cw-type zinc finger protein 4 | protein | 390 | 24% helix, 27% strand | Q8TE76 |
| B | Isoform 3 of morc family cw-type zinc finger protein 4 | protein | 386 | 25% helix, 27% strand | Q8TE76 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 915 | 0.83 | 0.84 | 107 | empty |
| 2 | 347 | 0.79 | 0.89 | 44 | MG, ANP |
| 3 | 262 | 0.79 | 0.91 | 36 | MG, ANP |
| 4 | 360 | 0.70 | 0.83 | 38 | empty |
| 5 | 363 | 0.66 | 0.80 | 44 | empty |
Interfaces
1 interface between chains.
- A–B · 2474 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7K7T · Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TE76 · AlphaFold monomer V2.0 prediction for morc family cw-type zinc finger protein 4 (Q8TE76) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TE76
- Elsewhere: RCSB PDB 7K7T · PDBe 7K7T · UniProt Q8TE76
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