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Transmembrane structure of TNFR1

Analyse Transmembrane structure of TNFR1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7K7A
Type: protein
Length: 90 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor receptor superfamily member 1A
UniProt: P19438
Pockets: 2 · best druggability 0.50

Structure

solution nmr · 1 distinct chain · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Tumor necrosis factor receptor superfamily member 1A	protein	30	80% helix, 0% strand	P19438

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.50	0.75	20	empty
2	50	0.29	0.75	13	empty

Interfaces

3 interfaces between chains.

A–B · 328 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 323 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 288 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7K7A · Transmembrane structure of TNFR1 · the same entry in another collection · chain A against A, TM-score 1.00
P19438 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19438
Elsewhere: RCSB PDB 7K7A · PDBe 7K7A · UniProt P19438

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