Research workbench
Marsupial T cell receptor SPL_145
Analyse Marsupial T cell receptor SPL_145 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7K0X
- Type
- protein
- Length
- 1,094 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T cell receptor mu chain; T cell receptor gamma chain
- Ligands
- NAG, BMA
- Pockets
- 14 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 3% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | T cell receptor mu chain | protein | 328 | 1% helix, 52% strand | — |
| D | T cell receptor gamma chain | protein | 219 | 6% helix, 53% strand | — |
| A | T cell receptor mu chain | protein | 330 | 1% helix, 52% strand | — |
| B | T cell receptor gamma chain | protein | 217 | 6% helix, 52% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains C, D, A, B
- BMA · beta-D-mannopyranose · sugar · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.64 | 0.84 | 27 | empty |
| 2 | 361 | 0.64 | 0.79 | 39 | empty |
| 3 | 510 | 0.62 | 0.75 | 55 | empty |
| 4 | 340 | 0.61 | 0.78 | 46 | empty |
| 5 | 444 | 0.57 | 0.73 | 44 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1952 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1861 Ų buried · 17 hydrogen bonds · protein-protein
- C–B · 557 Ų buried · 8 hydrogen bonds · protein-protein
- C–A · 58 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 6 glycan (disulfide, N-glycosylation).
Compared structures
- 7K0X · Marsupial T cell receptor Spl_145 · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7K0X · PDBe 7K0X
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.