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Structure of the SARS-cov-2 ORF8 encoded accessory protein

Analyse Structure of the SARS-cov-2 ORF8 encoded accessory protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7JX6
Type: protein
Length: 192 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ORF8 protein
UniProt: P0DTC8
Ligands: NA
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ORF8 protein	protein	104	0% helix, 51% strand	P0DTC8
B	ORF8 protein	protein	88	0% helix, 51% strand	P0DTC8

Ligands and binding sites

NA · Sodium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.47	0.76	29	NA

Interfaces

1 interface between chains.

A–B · 763 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

7JX6 · STRUCTURE OF THE SARS-CoV-2 ORF8 ENCODED ACCESSORY PROTEIN · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC8
Elsewhere: RCSB PDB 7JX6 · PDBe 7JX6 · UniProt P0DTC8

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