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Cbp bromodomain complexed with YF2-23

Analyse Cbp bromodomain complexed with YF2-23 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7JUO
Type: protein
Length: 904 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q92793
Ligands: YF2

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D, B, G, H, E	—	protein	113	—	Q92793
C	—	protein	112	—	Q92793
F	—	protein	114	—	Q92793

Ligands and binding sites

YF2 · N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide · ligand · 8 copies · chains A, B, D, C, F, E, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7JUO · CBP bromodomain complexed with YF2-23 · the same entry in another collection · chain C against C, TM-score 1.00
Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92793
Elsewhere: RCSB PDB 7JUO · PDBe 7JUO · UniProt Q92793

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