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Methionyl-tRNA synthetase from escherichia COLI complexed with methionine phosphonate

Analyse Methionyl-tRNA synthetase from escherichia COLI complexed with methionine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1P7P
Type: protein
Length: 545 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionyl-tRNA synthetase
EC: 6.1.1.10
UniProt: P00959
Ligands: MPH, ZN
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionyl-tRNA synthetase (EC 6.1.1.10)	protein	545	51% helix, 17% strand	P00959

Ligands and binding sites

MPH · (1-amino-3-methylsulfanyl-propyl)-phosphonic acid · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	478	0.65	0.77	59	MPH

Compared structures

1P7P · Methionyl-tRNA synthetase from Escherichia coli complexed with methionine phosphonate · the same entry in another collection · chain A against A, TM-score 1.00
P00959 · AlphaFold monomer V2.0 prediction for methionine--tRNA ligase (P00959) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00959
Elsewhere: RCSB PDB 1P7P · PDBe 1P7P · UniProt P00959

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