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Stalk of radial spoke 1 attached with doublet microtubule from chlamydomonas reinhardtii

Analyse Stalk of radial spoke 1 attached with doublet microtubule from chlamydomonas… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7JTS
Type
protein
Length
1,377 residues
Chains
13
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Radial spoke protein 3; Dynein 8 kda light chain, flagellar outer arm; FAP207; FAP253…
UniProt
A8J2J7, Q39580, A0A2K3DJP7, A0A2K3D359, A8IDP6
Pockets
16 · best druggability 0.79

Structure

electron microscopy · 6 distinct chains · 45% helix, 20% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ERadial spoke protein 3protein4045% helix, 15% strandA8J2J7
FRadial spoke protein 3protein4865% helix, 13% strandA8J2J7
a, b, c, d, e, f, g, hDynein 8 kda light chain, flagellar outer armprotein8435% helix, 35% strandQ39580
mFAP207protein1840% helix, 52% strandA0A2K3DJP7
sFAP253protein29067% helix, 5% strandA0A2K3D359
tCalmodulinprotein14357% helix, 4% strandA8IDP6

Pockets

16 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16560.790.8489empty
211200.780.80164empty
37310.780.8378empty
47440.770.8295empty
56190.720.8068empty

Interfaces

20 interfaces between chains.

  • a–s · 707 Ų buried · 4 hydrogen bonds · protein-protein
  • a–b · 565 Ų buried · 9 hydrogen bonds · protein-protein
  • e–f · 522 Ų buried · 12 hydrogen bonds · protein-protein
  • c–d · 498 Ų buried · 7 hydrogen bonds · protein-protein
  • s–t · 474 Ų buried · 3 hydrogen bonds · protein-protein

Compared structures

  • 7JTS · Stalk of radial spoke 1 attached with doublet microtubule from Chlamydomonas reinhardtii · the same entry in another collection · chain t against t, TM-score 1.00

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