Research workbench
Crystal structure of CFL2 wild-type from burkholderia cenocepacia
Analyse Crystal structure of CFL2 wild-type from burkholderia cenocepacia in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JQZ
- Type
- protein
- Length
- 2,940 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALPHA/BETA hydrolase fold
- UniProt
- B1K378
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | ALPHA/BETA hydrolase fold | protein | 294 | 41% helix, 20% strand | B1K378 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1185 | 0.82 | 0.83 | 132 | empty |
| 2 | 633 | 0.81 | 0.85 | 71 | empty |
| 3 | 1121 | 0.80 | 0.81 | 94 | empty |
| 4 | 822 | 0.79 | 0.82 | 84 | empty |
| 5 | 467 | 0.73 | 0.82 | 48 | empty |
Interfaces
20 interfaces between chains.
- I–J · 1258 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1244 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1240 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 1222 Ų buried · 7 hydrogen bonds · protein-protein
- G–H · 1222 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7JQZ · Crystal structure of Cfl2 wild-type from Burkholderia cenocepacia · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1K378
- Elsewhere: RCSB PDB 7JQZ · PDBe 7JQZ · UniProt B1K378
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