Research workbench
Structure of an endocytic receptor
Analyse Structure of an endocytic receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JPT
- Type
- protein
- Length
- 1,327 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lymphocyte antigen 75
- UniProt
- O60449
- Ligands
- NAG, BMA
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 15% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lymphocyte antigen 75 | protein | 1327 | 15% helix, 24% strand | O60449 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
- BMA · beta-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 449 | 0.83 | 0.90 | 60 | empty |
| 2 | 219 | 0.78 | 0.92 | 45 | empty |
| 3 | 971 | 0.77 | 0.79 | 110 | empty |
| 4 | 1189 | 0.76 | 0.78 | 107 | empty |
| 5 | 225 | 0.76 | 0.90 | 53 | empty |
Modifications
Observed in the structure: 23 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60449
- Elsewhere: RCSB PDB 7JPT · PDBe 7JPT · UniProt O60449
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