Research workbench
Crystal structure of shikimate dehydrogenase (aroe) from haemophilus influenzae
Analyse Crystal structure of shikimate dehydrogenase (aroe) from haemophilus influenzae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P74
- Type
- protein
- Length
- 533 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Shikimate 5-dehydrogenase
- EC
- 1.1.1.25
- UniProt
- P43876
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Shikimate 5-dehydrogenase (EC 1.1.1.25) | protein | 267 | 40% helix, 21% strand | P43876 |
| B | Shikimate 5-dehydrogenase (EC 1.1.1.25) | protein | 266 | 40% helix, 21% strand | P43876 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.67 | 0.80 | 35 | empty |
| 2 | 394 | 0.65 | 0.79 | 42 | empty |
| 3 | 171 | 0.49 | 0.77 | 24 | empty |
| 4 | 97 | 0.38 | 0.75 | 19 | empty |
| 5 | 88 | 0.35 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 416 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1P74 · Crystal structure of shikimate dehydrogenase (aroe) from haemophilus influenzae · the same entry in another collection · chain A against A, TM-score 1.00
- P43876 · AlphaFold monomer V2.0 prediction for shikimate dehydrogenase (NADP(+)) (P43876) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43876
- Elsewhere: RCSB PDB 1P74 · PDBe 1P74 · UniProt P43876
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