Research workbench
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector xopq
Analyse Structure of the activated ROQ1 resistosome directly recognizing the pathogen… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JLV
- Type
- protein
- Length
- 1,748 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disease resistance protein ROQ1
- EC
- 3.2.2.6
- UniProt
- A0A290U7C4
- Ligands
- ATP, MG
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 42% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, G | Disease resistance protein ROQ1 (EC 3.2.2.6) | protein | 437 | 42% helix, 10% strand | A0A290U7C4 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains A, B, D, G
- MG · Magnesium ion · metal · 4 copies · chains A, B, D, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 994 | 0.81 | 0.82 | 100 | ATP, MG |
| 2 | 436 | 0.74 | 0.84 | 63 | ATP, MG |
| 3 | 345 | 0.73 | 0.85 | 45 | empty |
| 4 | 282 | 0.71 | 0.85 | 39 | empty |
| 5 | 228 | 0.69 | 0.86 | 28 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1166 Ų buried · 10 hydrogen bonds · protein-protein
- D–G · 1165 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 1163 Ų buried · 10 hydrogen bonds · protein-protein
- A–G · 1158 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7JLV · Structure of the activated Roq1 resistosome directly recognizing the pathogen effector… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A290U7C4
- Elsewhere: RCSB PDB 7JLV · PDBe 7JLV · UniProt A0A290U7C4
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