Research workbench
2XVH FAB
Analyse 2XVH FAB in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JKB
- Type
- protein
- Length
- 449 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-lysozyme; Anti-HER2
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-lysozyme | protein | 223 | 5% helix, 49% strand | — |
| B | Anti-HER2 | protein | 226 | 7% helix, 44% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.65 | 0.74 | 71 | empty |
| 2 | 175 | 0.44 | 0.74 | 28 | empty |
| 3 | 83 | 0.39 | 0.78 | 16 | empty |
| 4 | 58 | 0.36 | 0.79 | 14 | empty |
| 5 | 65 | 0.29 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2093 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 7JKB · 2xVH Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7JKB · PDBe 7JKB
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