Research workbench

Cryo-EM structure of a proton-activated chloride channel

Analyse Cryo-EM structure of a proton-activated chloride channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7JI3
Type: protein
Length: 777 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proton-activated chloride channel
Pockets: 10 · best druggability 0.76

Structure

electron microscopy · 1 distinct chain · 30% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Proton-activated chloride channel	protein	259	30% helix, 34% strand	—

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	806	0.76	0.80	97	empty
2	92	0.74	0.96	36	empty
3	480	0.61	0.76	45	empty
4	259	0.52	0.75	24	empty
5	85	0.36	0.75	17	empty

Interfaces

3 interfaces between chains.

A–C · 1324 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 1307 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 1292 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7JI3 · Cryo-EM structure of a proton-activated chloride channel · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7JI3 · PDBe 7JI3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.