Research workbench
Type IV-B CRISPR complex
Analyse Type IV-B CRISPR complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7JHY
- Type
- protein + RNA
- Length
- 2,114 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CSF2 (CAS7); RNA (31-mer); CSF4 (CAS11)
- UniProt
- L0J6R6, L0JA79
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 30% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| e, d, c, f, b, a | CSF2 (CAS7) | protein | 228 | 18% helix, 22% strand | L0J6R6 |
| z | RNA (31-mer) | rna | 31 | — | — |
| h, g, j, k, i | CSF4 (CAS11) | protein | 143 | 48% helix, 0% strand | L0JA79 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1121 | 0.85 | 0.86 | 138 | empty |
| 2 | 987 | 0.84 | 0.86 | 134 | empty |
| 3 | 662 | 0.83 | 0.88 | 84 | empty |
| 4 | 347 | 0.79 | 0.89 | 47 | empty |
| 5 | 365 | 0.75 | 0.85 | 52 | empty |
Interfaces
25 interfaces between chains.
- d–z · 1240 Ų buried · 22 hydrogen bonds · protein-nucleic
- c–z · 1230 Ų buried · 14 hydrogen bonds · protein-nucleic
- e–z · 1193 Ų buried · 16 hydrogen bonds · protein-nucleic
- d–c · 1071 Ų buried · 10 hydrogen bonds · protein-protein
- e–f · 1036 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7JHY · Type IV-B CRISPR Complex · the same entry in another collection · chain e against e, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L0J6R6
- Every structure of UniProt L0JA79
- Elsewhere: RCSB PDB 7JHY · PDBe 7JHY · UniProt L0J6R6 · UniProt L0JA79
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