Research workbench
Human acidic fibroblast growth factor. 140 amino acid form with amino terminal his tag and LEU111 replaced with ile (L111I)
Analyse Human acidic fibroblast growth factor. 140 amino acid form with amino terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P63
- Type
- protein
- Length
- 281 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic fibroblast growth factor
- UniProt
- P05230
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acidic fibroblast growth factor | protein | 140 | 6% helix, 38% strand | P05230 |
| B | Acidic fibroblast growth factor | protein | 141 | 6% helix, 38% strand | P05230 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.41 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 444 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1P63 · Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1P63 · PDBe 1P63 · UniProt P05230
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