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Solution structure of the pathogenic mutant G131V of human prion protein (91-231)
Analyse Solution structure of the pathogenic mutant G131V of human prion protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7FHQ
- Type
- protein
- Length
- 142 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major prion protein
- UniProt
- P04156
- Pockets
- 3 · best druggability 0.40
Structure
solution nmr · 1 distinct chain · 35% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major prion protein | protein | 142 | 35% helix, 0% strand | P04156 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.40 | 0.81 | 13 | empty |
| 2 | 64 | 0.32 | 0.76 | 17 | empty |
| 3 | 66 | 0.30 | 0.75 | 17 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7FHQ · Solution structure of the pathogenic mutant G131V of Human prion protein (91-231) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04156
- Elsewhere: RCSB PDB 7FHQ · PDBe 7FHQ · UniProt P04156
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