Research workbench
Crystal structure of an orphan heme uptake protein (mhup) of ABC transporter from mycobacterium tuberculosis (form II)
Analyse Crystal structure of an orphan heme uptake protein (mhup) of ABC transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7FHP
- Type
- protein
- Length
- 584 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable periplasmic iron-transport lipoprotein
- UniProt
- L7N6B2
- Ligands
- SO4, SO3
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable periplasmic iron-transport lipoprotein | protein | 292 | 44% helix, 18% strand | L7N6B2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
- SO3 · Sulfite ion · ion · chains A
- GOL · Glycerol · additive · 4 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.74 | 0.78 | 65 | GOL |
| 2 | 847 | 0.71 | 0.76 | 62 | empty |
Interfaces
1 interface between chains.
- A–B · 669 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7FHP · Crystal structure of an orphan heme uptake protein (MhuP) of ABC transporter from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L7N6B2
- Elsewhere: RCSB PDB 7FHP · PDBe 7FHP · UniProt L7N6B2
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