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Discovery of DS15060524; gene targeting chimera (genetac) for the treatment of FRIEDREICH'S ataxia (frda)

Analyse Discovery of DS15060524; gene targeting chimera (genetac) for the treatment of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7FGT
Type: DNA
Length: 18 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*AP*AP*GP*AP*AP*GP*AP*AP*G)-3'); DNA (5'-D(*CP*TP*TP*CP*TP*TP*CP*TP*T)-3')
Ligands: 5R3

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA (5'-D(APAPGPAPAPGPAPAP*G)-3')	dna	9	—	—
B	DNA (5'-D(CPTPTPCPTPTPCPTP*T)-3')	dna	9	—	—

Ligands and binding sites

5R3 · ~{N}-[3-[3-(dimethylamino)propylamino]-3-oxidanylidene-propyl]-1-methyl-4-[3-[[1-methyl-4-[[1-methyl-4-[3-[[1-methyl-4-[(1-methylimidazol-2-yl) carbonylamino]pyrrol-2-yl]carbonylamino]propanoylamino]imidazol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]propanoylamino]imidazole-2-carboxamide · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 398 Å² buried · 31 hydrogen bonds · nucleic-nucleic

Compared structures

7FGT · Discovery of DS15060524; Gene targeting chimera (GeneTAC) for the treatment of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7FGT · PDBe 7FGT

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