Research workbench
Cryo-EM structure of apo bsclpp at pH 6.5
Analyse Cryo-EM structure of apo bsclpp at pH 6.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7FEQ
- Type
- protein
- Length
- 2,520 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease proteolytic subunit
- EC
- 3.4.21.92
- UniProt
- P80244
- Pockets
- 20 · best druggability 0.65
Structure
electron microscopy · 1 distinct chain · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, I, J, K, L, M, N, H | ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92) | protein | 180 | 34% helix, 17% strand | P80244 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.65 | 0.90 | 23 | empty |
| 2 | 107 | 0.64 | 0.89 | 22 | empty |
| 3 | 87 | 0.64 | 0.90 | 20 | empty |
| 4 | 112 | 0.64 | 0.88 | 25 | empty |
| 5 | 106 | 0.63 | 0.88 | 22 | empty |
Interfaces
35 interfaces between chains.
- D–E · 1319 Ų buried · 4 hydrogen bonds · protein-protein
- K–L · 1301 Ų buried · 5 hydrogen bonds · protein-protein
- A–G · 1298 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 1291 Ų buried · 8 hydrogen bonds · protein-protein
- F–G · 1283 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7FEQ · Cryo-EM structure of apo BsClpP at pH 6.5 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P80244
- Elsewhere: RCSB PDB 7FEQ · PDBe 7FEQ · UniProt P80244
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