Research workbench
Crystal structure of TTHMTA1-PTEMTA9 complex
Analyse Crystal structure of TTHMTA1-PTEMTA9 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F4S
- Type
- protein
- Length
- 1,152 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mt-A70 family protein; MTA9
- UniProt
- Q22GC0, A0E887
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 22% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mt-A70 family protein | protein | 178 | 22% helix, 22% strand | Q22GC0 |
| B | Mt-A70 family protein | protein | 178 | 22% helix, 20% strand | Q22GC0 |
| C | Mt-A70 family protein | protein | 176 | 25% helix, 22% strand | Q22GC0 |
| D | MTA9 | protein | 215 | 19% helix, 26% strand | A0E887 |
| E | MTA9 | protein | 213 | 21% helix, 15% strand | A0E887 |
| F | MTA9 | protein | 192 | 23% helix, 16% strand | A0E887 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 757 | 0.80 | 0.83 | 71 | empty |
| 2 | 881 | 0.79 | 0.82 | 74 | empty |
| 3 | 1130 | 0.79 | 0.81 | 108 | empty |
| 4 | 62 | 0.69 | 0.96 | 19 | empty |
| 5 | 224 | 0.67 | 0.84 | 32 | empty |
Interfaces
7 interfaces between chains.
- C–E · 1818 Ų buried · 32 hydrogen bonds · protein-protein
- A–D · 1608 Ų buried · 16 hydrogen bonds · protein-protein
- B–F · 1600 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 626 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 466 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7F4S · Crystal structure of TthMTA1-PteMTA9 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q22GC0
- Every structure of UniProt A0E887
- Elsewhere: RCSB PDB 7F4S · PDBe 7F4S · UniProt Q22GC0 · UniProt A0E887
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.