Crystal structure of yfih with C107A mutation in complex with endogenous udp-murnac

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• EPZ · (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy) phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid · ligand · 4 copies · chains A, B, C, D
• PO4 · Phosphate ion · ion · 2 copies · chains A, B
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7F3V · Crystal structure of YfiH with C107A mutation in complex with endogenous UDP-MurNAc · the same entry in another collection · chain A against A, TM-score 1.00
• P33644 · AlphaFold monomer V2.0 prediction for purine nucleoside phosphorylase yfih (P33644) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P33644
• Elsewhere: RCSB PDB 7F3V · PDBe 7F3V · UniProt P33644