Research workbench
Tbuox in complex with uric acid
Analyse Tbuox in complex with uric acid in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F2W
- Type
- protein
- Length
- 600 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uricase
- EC
- 1.7.3.3
- UniProt
- D6Y599
- Ligands
- URC
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Uricase (EC 1.7.3.3) | protein | 300 | 26% helix, 40% strand | D6Y599 |
Ligands and binding sites
- URC · Uric acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.67 | 0.76 | 68 | empty |
| 2 | 199 | 0.64 | 0.83 | 28 | URC |
| 3 | 198 | 0.62 | 0.82 | 35 | URC |
| 4 | 255 | 0.57 | 0.78 | 32 | empty |
| 5 | 155 | 0.47 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 3714 Ų buried · 62 hydrogen bonds · protein-protein
Compared structures
- 7F2W · TbUox in complex with uric acid · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D6Y599
- Elsewhere: RCSB PDB 7F2W · PDBe 7F2W · UniProt D6Y599
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