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Serum response factor accessory protein 1A (sap-1)/DNA complex

Analyse Serum response factor accessory protein 1A (sap-1)/DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1BC7
Type
protein + DNA
Length
115 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*GP*AP*CP*AP*GP*GP*AP*TP*GP*TP*G)-3'); DNA…
UniProt
P28324
Pockets
2 · best druggability 0.34

Structure

x-ray diffraction · 3 distinct chains · 41% helix, 15% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA (5'-D(*GP*AP*CP*AP*GP*GP*AP*TP*GP*TP*G)-3')dna11——
BDNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*TP*GP*TP*C)-3')dna11——
CProtein (ets-domain protein)protein9341% helix, 15% strandP28324

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1620.340.7717empty
2660.260.7214empty

Interfaces

3 interfaces between chains.

  • A–B · 492 Ų buried · 40 hydrogen bonds · nucleic-nucleic
  • B–C · 485 Ų buried · 9 hydrogen bonds · protein-nucleic
  • A–C · 426 Ų buried · 10 hydrogen bonds · protein-nucleic

Compared structures

  • 1BC7 · Serum response factor accessory protein 1A (sap-1)/DNA complex · the same entry in another collection · chain A against A, TM-score 1.00
  • P28324 · AlphaFold monomer V2.0 prediction for ets domain-containing protein elk-4 (P28324) · a predicted model of the same protein · chain C against A, TM-score 0.98

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