Research workbench
Crystal structure of mouse 14-3-3ZETA in complex with doubly phosphorylated ADAM22 peptide
Analyse Crystal structure of mouse 14-3-3ZETA in complex with doubly phosphorylated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EXE
- Type
- protein
- Length
- 459 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; Disintegrin and metalloproteinase domain-containing protein 22
- UniProt
- P63101, Q9R1V6
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein ZETA/DELTA | protein | 223 | 80% helix, 0% strand | P63101 |
| B | 14-3-3 protein ZETA/DELTA | protein | 224 | 83% helix, 0% strand | P63101 |
| C | Disintegrin and metalloproteinase domain-containing protein 22 | protein | 12 | 0% helix, 0% strand | Q9R1V6 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 287 | 0.52 | 0.75 | 25 | empty |
| 2 | 153 | 0.45 | 0.76 | 20 | empty |
| 3 | 77 | 0.35 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 996 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 596 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 506 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 7EXE · Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P63101 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63101) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9R1V6 · AlphaFold monomer V2.0 prediction for disintegrin and metalloproteinase domain-containing… · a predicted model of the same protein · chain C against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63101
- Every structure of UniProt Q9R1V6
- Elsewhere: RCSB PDB 7EXE · PDBe 7EXE · UniProt P63101 · UniProt Q9R1V6
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