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Structure of mumps virus nucleocapsid ring

Analyse Structure of mumps virus nucleocapsid ring in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7EWQ
Type
protein + RNA
Length
380 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Nucleoprotein; RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
UniProt
Q77IS8
Pockets
4 · best druggability 0.57

Structure

electron microscopy · 2 distinct chains · 60% helix, 5% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ANucleoproteinprotein37460% helix, 5% strandQ77IS8
BRNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')rna6——

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11530.570.8225empty
22490.500.7528empty
3820.400.7820empty
4870.350.7517empty

Interfaces

1 interface between chains.

  • A–B · 799 Ų buried · 20 hydrogen bonds · protein-nucleic

Compared structures

  • 7EWQ · Structure of Mumps virus nucleocapsid ring · the same entry in another collection · chain A against A, TM-score 1.00

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