Research workbench
Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum
Analyse Crystal structure of bifunctional indole-3-glycerol phosphate synthase /… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ETX
- Type
- protein
- Length
- 472 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan biosynthesis protein trpcf
- EC
- 4.1.1.48, 5.3.1.24
- UniProt
- P06560
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan biosynthesis protein trpcf (EC 4.1.1.48, 5.3.1.24) | protein | 472 | 40% helix, 18% strand | P06560 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.67 | 0.80 | 45 | empty |
| 2 | 192 | 0.52 | 0.78 | 31 | GOL |
| 3 | 117 | 0.49 | 0.80 | 22 | empty |
| 4 | 120 | 0.41 | 0.75 | 19 | empty |
| 5 | 102 | 0.37 | 0.75 | 28 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7ETX · Crystal structure of bifunctional indole-3-glycerol phosphate synthase /… · the same entry in another collection · chain A against A, TM-score 1.00
- P06560 · AlphaFold monomer V2.0 prediction for tryptophan biosynthesis protein trpcf (P06560) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06560
- Elsewhere: RCSB PDB 7ETX · PDBe 7ETX · UniProt P06560
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