Research workbench

Crystal structure of the complex formed by wolbachia cytoplasmic incompatibility factors cina and cinb with MN2+ from wpip

Analyse Crystal structure of the complex formed by wolbachia cytoplasmic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7ESZ
Type: protein
Length: 2,148 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bacteria factor B; Bacteria factor a
UniProt: B3CP74, B3CP73
Ligands: MN
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 4 distinct chains · 49% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bacteria factor B	protein	659	37% helix, 26% strand	B3CP74
B	Bacteria factor a	protein	408	71% helix, 2% strand	B3CP73
C	Bacteria factor B	protein	680	35% helix, 26% strand	B3CP74
D	Bacteria factor a	protein	401	70% helix, 2% strand	B3CP73

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1101	0.87	0.89	129	empty
2	636	0.86	0.91	82	empty
3	456	0.86	0.93	71	empty
4	654	0.78	0.83	79	empty
5	860	0.75	0.79	66	empty

Interfaces

5 interfaces between chains.

C–D · 2731 Å² buried · 47 hydrogen bonds · protein-protein
A–B · 2695 Å² buried · 47 hydrogen bonds · protein-protein
B–C · 589 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 470 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 124 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7ESZ · Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B3CP74
Every structure of UniProt B3CP73
Elsewhere: RCSB PDB 7ESZ · PDBe 7ESZ · UniProt B3CP74 · UniProt B3CP73

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.