Research workbench
Structure-guided studies of the holliday junction resolvase ruvx provide novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates
Analyse Structure-guided studies of the holliday junction resolvase ruvx provide novel… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ESS
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative pre-16S rRNA nuclease
- EC
- 3.1.-.-
- UniProt
- P9WGV7
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative pre-16S rRNA nuclease (EC 3.1.-.-) | protein | 149 | 46% helix, 21% strand | P9WGV7 |
| B | Putative pre-16S rRNA nuclease (EC 3.1.-.-) | protein | 151 | 44% helix, 23% strand | P9WGV7 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.66 | 0.87 | 34 | empty |
| 2 | 113 | 0.46 | 0.79 | 16 | empty |
| 3 | 120 | 0.41 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1035 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7ESS · Structure-guided studies of the Holliday junction resolvase RuvX provide novel insights… · the same entry in another collection · chain A against A, TM-score 1.00
- P9WGV7 · AlphaFold monomer V2.0 prediction for putative pre-16S rRNA nuclease (P9WGV7) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WGV7
- Elsewhere: RCSB PDB 7ESS · PDBe 7ESS · UniProt P9WGV7
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