Research workbench

The solution structure of a cytotoxic ribonuclease from the oocytes of rana catesbeiana (bullfrog), NMR, 15 structures

Analyse The solution structure of a cytotoxic ribonuclease from the oocytes of rana… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BC4
Type: protein
Length: 111 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease
EC: 3.1.27.5
UniProt: P11916
Pockets: 2 · best druggability 0.40

Structure

solution nmr · 1 distinct chain · 18% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease (EC 3.1.27.5)	protein	111	18% helix, 33% strand	P11916

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	119	0.40	0.75	27	empty
2	60	0.28	0.74	19	empty

Modifications

Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).

Compared structures

1BC4 · The solution structure of a cytotoxic ribonuclease from the oocytes of rana catesbeiana… · the same entry in another collection · chain A against A, TM-score 1.00
P11916 · AlphaFold monomer V2.0 prediction for oocytes ribonuclease (P11916) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11916
Elsewhere: RCSB PDB 1BC4 · PDBe 1BC4 · UniProt P11916

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.