Research workbench
Crystal structure of a transcription factor
Analyse Crystal structure of a transcription factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EQE
- Type
- protein
- Length
- 706 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TETR/ACRR family transcriptional regulator
- UniProt
- A0A4Z1DIH6
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TETR/ACRR family transcriptional regulator | protein | 179 | 70% helix, 0% strand | A0A4Z1DIH6 |
| B | TETR/ACRR family transcriptional regulator | protein | 170 | 77% helix, 0% strand | A0A4Z1DIH6 |
| C | TETR/ACRR family transcriptional regulator | protein | 179 | 73% helix, 0% strand | A0A4Z1DIH6 |
| D | TETR/ACRR family transcriptional regulator | protein | 178 | 74% helix, 0% strand | A0A4Z1DIH6 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.80 | 0.81 | 82 | empty |
| 2 | 1150 | 0.77 | 0.79 | 97 | empty |
| 3 | 189 | 0.62 | 0.83 | 21 | empty |
| 4 | 159 | 0.61 | 0.84 | 21 | empty |
| 5 | 174 | 0.59 | 0.82 | 21 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1427 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1214 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 394 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 61 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 7EQE · Crystal Structure of a transcription factor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A4Z1DIH6
- Elsewhere: RCSB PDB 7EQE · PDBe 7EQE · UniProt A0A4Z1DIH6
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