Research workbench

Crystal structure of ZER1 bound to gflh degron

Analyse Crystal structure of ZER1 bound to gflh degron in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EP4
Type: protein
Length: 489 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein zer-1 homolog
UniProt: Q7Z7L7
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Protein zer-1 homolog	protein	245	71% helix, 1% strand	Q7Z7L7
A	Protein zer-1 homolog	protein	244	69% helix, 1% strand	Q7Z7L7

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.64	0.81	52	empty
2	166	0.43	0.74	27	empty
3	71	0.41	0.79	12	empty

Interfaces

1 interface between chains.

B–A · 1464 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

7EP4 · Crystal structure of ZER1 bound to GFLH degron · the same entry in another collection · chain B against B, TM-score 1.00
Q7Z7L7 · AlphaFold monomer V2.0 prediction for protein zer-1 homolog (Q7Z7L7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z7L7
Elsewhere: RCSB PDB 7EP4 · PDBe 7EP4 · UniProt Q7Z7L7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.