Research workbench
Mitf hlhlz delta ake
Analyse Mitf hlhlz delta ake in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EOD
- Type
- protein
- Length
- 271 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform M1 of microphthalmia-associated transcription factor
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform M1 of microphthalmia-associated transcription factor | protein | 70 | 77% helix, 0% strand | — |
| B | Isoform M1 of microphthalmia-associated transcription factor | protein | 66 | 80% helix, 0% strand | — |
| C | Isoform M1 of microphthalmia-associated transcription factor | protein | 66 | 80% helix, 0% strand | — |
| D | Isoform M1 of microphthalmia-associated transcription factor | protein | 69 | 77% helix, 0% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · 11 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.47 | 0.73 | 28 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1771 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1769 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 264 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 148 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 55 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7EOD · MITF HLHLZ Delta AKE · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7EOD · PDBe 7EOD
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