Research workbench
Structure of monomeric complex of macv L bound to Z and 3'-vrna
Analyse Structure of monomeric complex of macv L bound to Z and 3'-vrna in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ELC
- Type
- protein + RNA
- Length
- 1,465 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; Ring finger protein Z; 3'-vrna promoter
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- Q6IVU0, Q6UY77
- Ligands
- ZN, MN
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 3 distinct chains · 45% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1409 | 45% helix, 10% strand | Q6IVU0 |
| B | Ring finger protein Z | protein | 49 | 16% helix, 8% strand | Q6UY77 |
| C | 3'-vrna promoter | rna | 7 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1183 | 0.73 | 0.76 | 104 | empty |
| 2 | 551 | 0.70 | 0.79 | 63 | empty |
| 3 | 465 | 0.67 | 0.79 | 54 | empty |
| 4 | 319 | 0.65 | 0.81 | 41 | empty |
| 5 | 397 | 0.65 | 0.79 | 54 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1112 Ų buried · 24 hydrogen bonds · protein-nucleic
- A–B · 944 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7ELC · Structure of monomeric complex of MACV L bound to Z and 3'-vRNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IVU0
- Every structure of UniProt Q6UY77
- Elsewhere: RCSB PDB 7ELC · PDBe 7ELC · UniProt Q6IVU0 · UniProt Q6UY77
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