Research workbench

CRCLPP-S2C

Analyse CRCLPP-S2C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EKQ
Type: protein
Length: 3,583 residues
Chains: 19
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent clp protease proteolytic subunit; ATP-dependent clp protease ATP-binding…
EC: 3.4.21.92
UniProt: A8INX1, A8IL21, A8IJ60, P42380, A0A2K3CXW8, A8IXD6, A8IS47, A8IH07, A8J353, A8J3C3, A8IJY7, A0A2K3DG79
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 16 distinct chains · 36% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent clp protease proteolytic subunit	protein	227	39% helix, 17% strand	A8INX1
B, D	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	193	46% helix, 18% strand	A8IL21
C, E	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	174	42% helix, 20% strand	A8IJ60
F	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	172	45% helix, 19% strand	A8IL21
G	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	179	42% helix, 19% strand	A8IJ60
H	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	148	43% helix, 18% strand	P42380
I	ATP-dependent clp protease proteolytic subunit	protein	217	36% helix, 16% strand	A0A2K3CXW8
J	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	165	49% helix, 17% strand	P42380
K	ATP-dependent clp protease proteolytic subunit	protein	233	36% helix, 13% strand	A8IXD6
L	ATP-dependent clp protease proteolytic subunit	protein	187	42% helix, 19% strand	A8IS47
M	ATP-dependent clp protease proteolytic subunit (EC 3.4.21.92)	protein	133	43% helix, 25% strand	P42380
N	ATP-dependent clp protease proteolytic subunit	protein	338	41% helix, 10% strand	A8IH07
O	ATP-dependent clp protease ATP-binding subunit CLPT4, chloroplastic	protein	162	60% helix, 4% strand	A8J353
P	Chaperonin 11	protein	95	4% helix, 26% strand	A8J3C3
Q	Chaperonin 23	protein	205	0% helix, 32% strand	A8IJY7
R, S	CPN20 co-chaperonin subunit	protein	194	3% helix, 29% strand	A0A2K3DG79

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1141	0.79	0.81	112	empty
2	525	0.77	0.84	65	empty
3	298	0.76	0.88	43	empty
4	1050	0.76	0.78	111	empty
5	793	0.75	0.79	100	empty

Interfaces

53 interfaces between chains.

A–B · 2213 Å² buried · 15 hydrogen bonds · protein-protein
K–L · 1865 Å² buried · 13 hydrogen bonds · protein-protein
H–N · 1644 Å² buried · 23 hydrogen bonds · protein-protein
J–K · 1460 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 1385 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7EKQ · CrClpP-S2c · the same entry in another collection · chain S against S, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8INX1
Every structure of UniProt A8IL21
Every structure of UniProt A8IJ60
Every structure of UniProt P42380
Every structure of UniProt A0A2K3CXW8
Every structure of UniProt A8IXD6
Every structure of UniProt A8IS47
Every structure of UniProt A8IH07
Every structure of UniProt A8J353
Every structure of UniProt A8J3C3
Every structure of UniProt A8IJY7
Every structure of UniProt A0A2K3DG79
Elsewhere: RCSB PDB 7EKQ · PDBe 7EKQ · UniProt A8INX1 · UniProt A8IL21 · UniProt A8IJ60 · UniProt P42380 · UniProt A0A2K3CXW8 · UniProt A8IXD6 · UniProt A8IS47 · UniProt A8IH07 · UniProt A8J353 · UniProt A8J3C3 · UniProt A8IJY7 · UniProt A0A2K3DG79

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