Research workbench
Junin VIRUS(JUNV) RNA polymerase L complexed with Z protein
Analyse Junin VIRUS(JUNV) RNA polymerase L complexed with Z protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EJU
- Type
- protein
- Length
- 1,700 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; Ring finger protein Z
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- A0A0M4LRT1, Q6IVU5
- Ligands
- ZN, MG
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 39% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1648 | 39% helix, 6% strand | A0A0M4LRT1 |
| B | Ring finger protein Z | protein | 52 | 19% helix, 8% strand | Q6IVU5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1082 | 0.84 | 0.85 | 105 | empty |
| 2 | 117 | 0.77 | 0.96 | 33 | empty |
| 3 | 618 | 0.76 | 0.82 | 62 | empty |
| 4 | 798 | 0.75 | 0.80 | 79 | empty |
| 5 | 168 | 0.73 | 0.90 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1079 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7EJU · Junin virus(JUNV) RNA polymerase L complexed with Z protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0M4LRT1
- Every structure of UniProt Q6IVU5
- Elsewhere: RCSB PDB 7EJU · PDBe 7EJU · UniProt A0A0M4LRT1 · UniProt Q6IVU5
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