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Crystal structure of MEI2 RRM3

Analyse Crystal structure of MEI2 RRM3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EIO
Type: protein
Length: 292 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Meiosis protein MEI2
UniProt: P08965
Ligands: SO4
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Meiosis protein MEI2	protein	146	29% helix, 24% strand	P08965

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.60	0.91	19	empty
2	294	0.52	0.74	42	empty

Interfaces

1 interface between chains.

A–B · 695 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7EIO · Crystal Structure of Mei2 RRM3 · the same entry in another collection · chain A against A, TM-score 1.00
P08965 · AlphaFold monomer V2.0 prediction for meiosis protein MEI2 (P08965) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08965
Elsewhere: RCSB PDB 7EIO · PDBe 7EIO · UniProt P08965

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