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Structure of thermotoga maritima GH5 endoglucanase TM1752 in complex with tris

Analyse Structure of thermotoga maritima GH5 endoglucanase TM1752 in complex with tris in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EFZ
Type: protein
Length: 648 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoglucanase
UniProt: Q9X274
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Endoglucanase	protein	324	36% helix, 19% strand	Q9X274

Ligands and binding sites

IPA · Isopropyl alcohol · additive · 3 copies · chains A, B
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	653	0.69	0.77	67	TRS
2	566	0.66	0.77	76	TRS
3	245	0.55	0.77	25	empty
4	53	0.33	0.77	12	IPA

Interfaces

1 interface between chains.

A–B · 579 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7EFZ · Structure of Thermotoga maritima GH5 endoglucanase TM1752 in complex with TRIS · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X274
Elsewhere: RCSB PDB 7EFZ · PDBe 7EFZ · UniProt Q9X274

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