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Fructose-bisphosphate aldolase in artemisia sieversiana pollen

Analyse Fructose-bisphosphate aldolase in artemisia sieversiana pollen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7EFS
Type: protein
Length: 1,357 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase
Pockets: 16 · best druggability 0.90

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Fructose-bisphosphate aldolase	protein	339	46% helix, 15% strand	—
D	Fructose-bisphosphate aldolase	protein	340	46% helix, 15% strand	—

Pockets

16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1069	0.90	0.92	161	empty
2	210	0.79	0.93	35	empty
3	67	0.71	0.96	20	empty
4	489	0.68	0.79	60	empty
5	299	0.60	0.79	32	empty

Interfaces

6 interfaces between chains.

A–B · 1126 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 1098 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 861 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 852 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 103 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7EFS · Fructose-bisphosphate aldolase in Artemisia sieversiana pollen · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7EFS · PDBe 7EFS

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