Research workbench
The csy-ACRIF14-dsdna complex
Analyse The csy-ACRIF14-dsdna complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ECW
- Type
- protein + DNA + RNA
- Length
- 3,004 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type I-F CRISPR-associated protein CSY1; CRISPR type I-F/YPEST-associated protein CSY2…
- UniProt
- A0A3A8DDU9, B3G161, A0A659BSG0, A0A0R6PCL0
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 10 distinct chains · 27% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type I-F CRISPR-associated protein CSY1 | protein | 424 | 38% helix, 8% strand | A0A3A8DDU9 |
| B | CRISPR type I-F/YPEST-associated protein CSY2 | protein | 305 | 21% helix, 28% strand | B3G161 |
| C | CRISPR-associated protein CSY3 | protein | 293 | 21% helix, 21% strand | A0A659BSG0 |
| D, G, H | CRISPR-associated protein CSY3 | protein | 333 | 22% helix, 24% strand | A0A659BSG0 |
| E | CRISPR-associated protein CSY3 | protein | 330 | 25% helix, 25% strand | A0A659BSG0 |
| F | CRISPR-associated protein CSY3 | protein | 335 | 24% helix, 26% strand | A0A659BSG0 |
| I, J | ACRIF14 | protein | 124 | 44% helix, 17% strand | A0A0R6PCL0 |
| M | RNA (60-mer) | rna | 44 | — | — |
| N | 54-mer DNA | dna | 13 | — | — |
| O | 54-mer DNA | dna | 13 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 998 | 0.86 | 0.87 | 112 | empty |
| 2 | 1101 | 0.85 | 0.86 | 127 | empty |
| 3 | 1161 | 0.83 | 0.84 | 121 | empty |
| 4 | 877 | 0.83 | 0.85 | 92 | empty |
| 5 | 1098 | 0.82 | 0.84 | 100 | empty |
Interfaces
38 interfaces between chains.
- A–B · 3769 Ų buried · 36 hydrogen bonds · protein-protein
- F–G · 2117 Ų buried · 21 hydrogen bonds · protein-protein
- E–F · 1932 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 1914 Ų buried · 17 hydrogen bonds · protein-protein
- G–H · 1908 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7ECW · The Csy-AcrIF14-dsDNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3A8DDU9
- Every structure of UniProt B3G161
- Every structure of UniProt A0A659BSG0
- Every structure of UniProt A0A0R6PCL0
- Elsewhere: RCSB PDB 7ECW · PDBe 7ECW · UniProt A0A3A8DDU9 · UniProt B3G161 · UniProt A0A659BSG0 · UniProt A0A0R6PCL0
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