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The structure of cytosolic tapgi

Analyse The structure of cytosolic tapgi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E77
Type: protein
Length: 2,222 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose-6-phosphate isomerase
EC: 5.3.1.9
UniProt: Q1PBI3
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 3 distinct chains · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	562	52% helix, 11% strand	Q1PBI3
B, D	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	549	54% helix, 11% strand	Q1PBI3
C	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	562	53% helix, 12% strand	Q1PBI3

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1038	0.82	0.83	71	empty
2	936	0.82	0.83	69	empty
3	482	0.72	0.82	48	empty
4	472	0.70	0.81	49	empty
5	450	0.70	0.81	48	empty

Interfaces

3 interfaces between chains.

A–C · 6940 Å² buried · 111 hydrogen bonds · protein-protein
B–D · 6419 Å² buried · 95 hydrogen bonds · protein-protein
A–B · 107 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7E77 · The structure of cytosolic TaPGI · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt Q1PBI3
Elsewhere: RCSB PDB 7E77 · PDBe 7E77 · UniProt Q1PBI3

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