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Crystal structure of human coronavirus NL63 3C-like protease
Analyse Crystal structure of human coronavirus NL63 3C-like protease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7E6M
- Type
- protein
- Length
- 598 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3C-like proteinase
- EC
- 3.4.22.-
- UniProt
- P0C6U6
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 3C-like proteinase (EC 3.4.22.-) | protein | 299 | 24% helix, 29% strand | P0C6U6 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 956 | 0.72 | 0.76 | 82 | empty |
| 2 | 488 | 0.65 | 0.77 | 62 | empty |
| 3 | 507 | 0.63 | 0.76 | 61 | empty |
| 4 | 146 | 0.43 | 0.75 | 27 | empty |
| 5 | 106 | 0.38 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1045 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7E6M · Crystal structure of Human coronavirus NL63 3C-like protease · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C6U6
- Elsewhere: RCSB PDB 7E6M · PDBe 7E6M · UniProt P0C6U6
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