Research workbench
Glucose-6-phosphate dehydrogenase from kluyveromyces lactis
Analyse Glucose-6-phosphate dehydrogenase from kluyveromyces lactis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7E6H
- Type
- protein
- Length
- 484 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate 1-dehydrogenase
- EC
- 1.1.1.49
- UniProt
- P48828
- Pockets
- 7 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) | protein | 484 | 37% helix, 21% strand | P48828 |
Ligands and binding sites
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
- 7PE · 2-(2-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy) ethoxy)ethanol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.47 | 0.73 | 32 | empty |
| 2 | 212 | 0.47 | 0.74 | 31 | empty |
| 3 | 57 | 0.45 | 0.84 | 16 | empty |
| 4 | 69 | 0.35 | 0.76 | 12 | empty |
| 5 | 69 | 0.31 | 0.74 | 14 | empty |
Compared structures
- 7E6H · glucose-6-phosphate dehydrogenase from Kluyveromyces lactis · the same entry in another collection · chain A against A, TM-score 1.00
- P48828 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P48828) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48828
- Elsewhere: RCSB PDB 7E6H · PDBe 7E6H · UniProt P48828
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.