Mouse TAB2 nzf in complex with LYS6-linked diubiquitin

Structure

x-ray diffraction · 4 distinct chains · 22% helix, 32% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains C, J
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

9 interfaces between chains.

• B–C · 460 Ų buried · 8 hydrogen bonds · protein-protein
• A–H · 450 Ų buried · 4 hydrogen bonds · protein-protein
• I–J · 450 Ų buried · 6 hydrogen bonds · protein-protein
• A–C · 404 Ų buried · 5 hydrogen bonds · protein-protein
• H–J · 382 Ų buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 2 isopeptide (isopeptide).

Compared structures

• 7E62 · Mouse TAB2 NZF in complex with Lys6-linked diubiquitin · the same entry in another collection · chain J against J, TM-score 1.00
• P62983 · AlphaFold monomer V2.0 prediction for ubiquitin-40S ribosomal protein S27A (P62983) · a predicted model of the same protein · chain B against A, TM-score 0.96
• Q99K90 · AlphaFold monomer V2.0 prediction for TGF-beta-activated kinase 1 and MAP3K7-binding… · a predicted model of the same protein · chain C against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62983
• Every structure of UniProt Q99K90
• Elsewhere: RCSB PDB 7E62 · PDBe 7E62 · UniProt P62983 · UniProt Q99K90