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The crystal structure of peptidoglycan peptidase in complex with inhibitor 1

Analyse The crystal structure of peptidoglycan peptidase in complex with inhibitor 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E60
Type: protein
Length: 255 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peptidase M23
UniProt: A0A1J6PWI8
Ligands: HX9, ZN
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peptidase M23	protein	255	12% helix, 44% strand	A0A1J6PWI8

Ligands and binding sites

HX9 · (2~{R},6~{S})-2,6-diacetamido-7-[[(2~{R})-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-7-oxidanylidene-heptanoic acid · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	331	0.55	0.75	32	HX9
2	144	0.47	0.77	27	empty

Compared structures

7E60 · The crystal structure of peptidoglycan peptidase in complex with inhibitor 1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1J6PWI8
Elsewhere: RCSB PDB 7E60 · PDBe 7E60 · UniProt A0A1J6PWI8

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