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Cryo-EM structure of alpha 7 homo-tetradecamer

Analyse Cryo-EM structure of alpha 7 homo-tetradecamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E55
Type: protein
Length: 244 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome subunit alpha type-3
UniProt: P25788
Pockets: 3 · best druggability 0.40

Structure

electron microscopy · 1 distinct chain · 36% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proteasome subunit alpha type-3	protein	244	36% helix, 21% strand	P25788

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.40	0.77	25	empty
2	67	0.40	0.80	15	empty
3	65	0.36	0.78	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7E55 · Cryo-EM structure of alpha 7 homo-tetradecamer · the same entry in another collection · chain A against A, TM-score 1.00
P25788 · AlphaFold monomer V2.0 prediction for proteasome subunit alpha type-3 (P25788) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25788
Elsewhere: RCSB PDB 7E55 · PDBe 7E55 · UniProt P25788

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