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Crystal structure of sdr family NAD(P)-dependent oxidoreductase from exiguobacterium

Analyse Crystal structure of sdr family NAD(P)-dependent oxidoreductase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E3X
Type: protein
Length: 496 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Oxidoreductase
UniProt: A0A177S9P4
Ligands: NAP
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Oxidoreductase	protein	248	45% helix, 19% strand	A0A177S9P4

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.77	0.84	55	NAP
2	489	0.77	0.84	55	NAP

Interfaces

1 interface between chains.

A–B · 1909 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7E3X · Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A177S9P4
Elsewhere: RCSB PDB 7E3X · PDBe 7E3X · UniProt A0A177S9P4

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