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Crystal structure of the rwd domain of human GCN2 - 2

Analyse Crystal structure of the rwd domain of human GCN2 - 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7E2M
Type: protein
Length: 775 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Eif-2-alpha kinase GCN2
EC: 2.7.11.1
UniProt: Q9P2K8
Pockets: 5 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Eif-2-alpha kinase GCN2 (EC 2.7.11.1)	protein	130	38% helix, 19% strand	Q9P2K8
B, C, D, E, F	Eif-2-alpha kinase GCN2 (EC 2.7.11.1)	protein	129	36% helix, 19% strand	Q9P2K8

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1136	0.80	0.81	125	empty
2	87	0.50	0.83	22	empty
3	52	0.42	0.84	15	empty
4	81	0.42	0.80	23	empty
5	62	0.40	0.80	16	empty

Interfaces

9 interfaces between chains.

A–B · 1324 Å² buried · 24 hydrogen bonds · protein-protein
E–F · 1310 Å² buried · 25 hydrogen bonds · protein-protein
C–D · 1290 Å² buried · 21 hydrogen bonds · protein-protein
A–E · 268 Å² buried · 5 hydrogen bonds · protein-protein
A–F · 258 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7E2M · Crystal structure of the RWD domain of human GCN2 - 2 · the same entry in another collection · chain F against F, TM-score 1.00
Q9P2K8 · AlphaFold monomer V2.0 prediction for eif-2-alpha kinase GCN2 (Q9P2K8) · a predicted model of the same protein · chain C against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9P2K8
Elsewhere: RCSB PDB 7E2M · PDBe 7E2M · UniProt Q9P2K8

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