Research workbench
Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, in complex with the product imp
Analyse Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1P19
- Type
- protein
- Length
- 742 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- Q27796
- Ligands
- IMP
- Pockets
- 11 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 27% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 187 | 24% helix, 33% strand | Q27796 |
| B | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 184 | 32% helix, 32% strand | Q27796 |
| C | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 185 | 26% helix, 31% strand | Q27796 |
| D | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 186 | 28% helix, 33% strand | Q27796 |
Ligands and binding sites
- IMP · Inosinic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.62 | 0.83 | 23 | empty |
| 2 | 376 | 0.61 | 0.77 | 37 | IMP |
| 3 | 298 | 0.61 | 0.79 | 37 | empty |
| 4 | 320 | 0.59 | 0.77 | 33 | IMP |
| 5 | 376 | 0.58 | 0.75 | 39 | IMP |
Interfaces
3 interfaces between chains.
- A–B · 1755 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1703 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 313 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1P19 · Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q27796
- Elsewhere: RCSB PDB 1P19 · PDBe 1P19 · UniProt Q27796
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